Interplay between transglutaminases and heparan sulphate in progressive renal scarring
نویسندگان
چکیده
منابع مشابه
Interplay between transglutaminases and heparan sulphate in progressive renal scarring
Transglutaminase-2 (TG2) is a new anti-fibrotic target for chronic kidney disease, for its role in altering the extracellular homeostatic balance leading to excessive build-up of matrix in kidney. However, there is no confirmation that TG2 is the only transglutaminase involved, neither there are strategies to control its action specifically over that of the conserved family-members. In this stu...
متن کاملInterferon and heparan sulphate.
In 1954, substances that protected cells from viral infection were discovered and named IFN (interferon). This family of cytokines, which were the first to be used in clinical therapy, is classified into type I and II IFNs. Type I mainly consists of IFNalpha and IFNbeta subtypes, which are structurally related and bind to a common receptor. IFNgamma, the sole type II IFN, is structurally unrela...
متن کاملHeparan sulphate alterations in tumour cells.
Heparan sulphate proteoglycan is widely distributed, being found inserted into plasma membranes of most cells (Kjellenetal., 1981 ; Norlingetal., 1981)and asa significant component of basement membranes (Kanwar et al., 1980; Hassel et al., 1980). As a strong polyanion, heparan sulphate interacts with many components under physiological conditions, the specificity of these interactions depending...
متن کاملProgressive scarring facial lesions in a boy
Hydroa vacciniforme is a photosensitivity disorder characterized by the childhood onset of necrotic vesiculopapules on exposed areas. We present a case of a 10-year-old boy with a 1-year history of papular lesions over his face. In this report, we discuss the in-depth histology of hydroa vacciniforme, and the management options.
متن کاملStructure-activity relationship of heparan sulphate.
HS influences fundamental cellular properties and biochemical processes at the cell surface. In addition to the issues already discussed, it has a profound effect on cell adhesion and migration through its interaction with many extracellular matrix proteins, most notably fibronectin and thrombospondin; it is closely linked to lipid metabolism through its capacity to bind low-density lipoprotein...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep31343